Cannabis 101

Learn all about cannabis

Consumption Methods

Gaining the mental and physical benefits of cannabis is largely dependent upon how it's consumed, with each method providing a unique experience and host of effects. There are three basic delivery methods: inhalation, oral, and topical. Under these umbrella methods are various techniques that serve unique functions, each appropriate for treating different conditions.

Smoking

This ancient custom is the method most commonly associated with cannabis. However, advances in vaporization technology have offered smokers an alternative method with fewer health concerns. The effects associated with smoking are widely debated, but health professionals are in agreement that smoke-free methods pose less risk and are medically preferred.

Cannabis smokers have a wide array of devices at their disposal, including hand pipes, water pipes, rolling papers, and hookahs. Each of these provides different experiences and influences the grade of smoke inhaled.

Vaporization

Vaporizers are the logical choice for moderate to experienced and/or health-conscious cannabis consumers. A vaporizer steadily heats herbs to a temperature that is high enough to extract THC, CBD, and other cannabinoids but too low for the potentially harmful toxins that are released during combustion; essentially, vaporization eliminates the health risks associated with smoking. This improvement comes with an equally significant reduction in odor, which is generally the first acknowledgment of first-time vaporizer users. There is a diverse landscape of vaporizer models and the market is only expanding as the technology improves.

There are multiple elements that distinguish vaporizer designs, markedly portability, and product. As the market grows, so does the efficiency and quality of portable models, which generally fall short of fixed models (requiring an outlet power source) in durability and robustness. The form of cannabis product is the other primary component: many vaporizers take cannabis concentrates which come in a variety of forms including oil and wax. These can be added manually or using cartridges, depending on the design. The prevalence of concentrate vapes is due to mechanical simplicity; fewer vaporizers take flower, which require a heating element to accomplish vaporization, and thus a more sophisticated design.

A younger delivery method that is a point of contention amongst the cannabis community and attentive policymakers is dabbing. Dabbing is a form of vaporization in which potent cannabis concentrates are dropped on a heated nail, creating vapor that is trapped in a glass globe and inhaled. Although there are obvious health benefits associated with clean concentrates over combustible flower, concerns arise from dabbing's image and the intense effects of high-THC extracts.

Tinctures

Tinctures are a liquid cannabis extract used by consumers looking for dosage control and fast-acting effects without the health risks associated with smoking. Most commonly, alcohol is used as the solvent (any proof greater than 80 can be used effectively), but other fat-soluble liquids can be used as well, such as vinegar or glycerol. Generally, three or four drops of the tincture are placed under the tongue, where it’s absorbed into the body versus swallowed and digested. When ingested, tinctures are immediately absorbed in an empty stomach but require time to process through the liver, reducing dosage control.

Ingestible Oils

Ingestible oils are a happy medium between edibles and concentrates: they are swallowed and digested like an infused product but often have the consistency of oil. These oils can either be eaten or put in easily ingested capsules. One popular oil is Rick Simpson Oil (RSO), which originated in 2003 when Simpson used hemp to treat his skin cancer. RSO is made by extracting the therapeutic compounds of cannabis with alcohol and then evaporating the solvent, leaving behind a tar-like substance resembling oil.

Edibles

Eating or drinking cannabis provides significantly different effects from delivery methods that immediately enter the bloodstream, such as smoking or vaping. Edibles can be defined as any food that contains cannabis, whether or not the cannabinoids are bioavailable. These products have longer onsets and tend to cause powerful full-body, psychoactive effects.

Infused food and drinks can be made in a variety of ways depending on the dish. Most often, edibles are infused with a staple infused ingredient high in fat -- like butter or olive oil -- that enables extraction of the plant’s therapeutic properties. Adding tinctures to dishes is another great option for dosage control and simplicity. Generally, cooking with cannabis flower can be difficult because of the complications associated with cannabinoid activation (including sensitive heating temperatures and times, and sufficient solvent fat). However, as the prevalence of cannabis grows, so does the presence of flower in the kitchen.

Topicals, Creams, And Lotions

Topical cannabis administration utilizes full cannabis extract -- a thick oil that has been decarboxylated to activate cannabinoids. Once cannabinoids are activated, they can be absorbed through your skin. Topical effects differ from other medicating methods in that they don’t provide the cerebral stimulation that users describe as "being high." Because of this, topicals are appropriate for consumers needing a clear head and localized relief (for example, muscle aches or soreness).

FAQs

Here we'll cover some of the fundamentals... If you're new to cannabis or rediscovering it for the first time in years, you're sure to find the answers to these cannabis basics useful. These common questions are a great starting point to build the foundation of your knowledge of cannabis flowers and their therapeutic effects.

A brief history of cannabis

Humans have cultivated and consumed the flowering tops of female cannabis plants since virtually the beginning of recorded history. Cannabis-based textiles dating to 7,000 B.C. have been recovered in northern China, and the plant's use as a medicinal and euphoric agent date back nearly as far. In 2008, archeologists in Central Asia discovered over two pounds of cannabis in the 2,700-year-old grave of an ancient mummified shaman. After scientists conducted extensive testing on the material's potency, they affirmed, The most probable conclusion ... is that ancient cultures cultivated cannabis for pharmaceutical, psychoactive, and divinatory purposes.

Modern cultures continue to utilize cannabis for these same purposes, despite a present-day, nearly worldwide ban on the plant's cultivation and consumption imposed by various governments. In the United States, Congress initially imposed federal prohibitions outlawing cannabis' recreational, industrial, and therapeutic use by the passage of the Marihuana Tax Act of 1937. This federal prohibition was later reaffirmed by Congress' decision to classify marijuana - as well as all of the plant's active compounds, known as cannabinoids - as Schedule I substances under the Controlled Substances Act of 1970.

Despite the U.S. government's nearly century-long prohibition of the plant, scientists in America and around the world have continued to closely study the plant and its effects on living organisms, including in clinical trials. In recent years, scientists' interest in the plant and its active constituents, known as cannabinoids, has increased exponentially. Scientific study of the cannabis plant has now identified over 60 unique, biologically active cannabinoids - such as THC, THCV, CBD, THCA, CBC, and CBG, among others - many of which possess documented therapeutic properties. A recent meta-analysis of these compounds identifies well over a dozen therapeutic properties attributable to cannabinoids, including neuroprotective, anti-cancer, anti-bacterial, and anti-diabetic properties. To date, there are over 22,000 published studies or reviews in the scientific literature pertaining to the cannabis plant and its cannabinoids.

The many uses of this multi-faceted plant

Historically, humans have used various parts of the cannabis plant for a multitude of purposes. Most people today are readily aware that cannabis is consumed socially as a mood enhancer. By contrast, certain varieties of cannabis - as well as most parts of the plant, including the seeds and the stalk - contain virtually no psychoactive properties but may be utilized in other ways. For example, ground seeds from the cannabis plant contain high and balanced levels of essential amino acids and essential fatty acids and may be baked into a variety of nutritional food-stuffs. Oil can also be processed from cannabis seeds and consumed as a nutritional supplement

The stalk of the marijuana plant, primarily of the cannabis sativa variety - which can grow as high as 20 feet in height - can also be harvested for its fiber content. This renewable resource is a common source of paper, rope, clothing, and building materials. Most industrialized nations, including Canada, Japan, Australia, and the European Union, regulate the commercial production of low THC varieties of cannabis for industrial purposes. During World War II the U.S. government commissioned tens of thousands of domestic farmers to grow cannabis to assist with America's wartime needs. Following the War's conclusion, however, the United States government imposed a complete ban on the domestic production of the plant, including the cultivation of non-psychoactive cannabis sativa varieties.

The plant's cannabinoids are largely responsible for cannabis' physiological, mood-altering, and therapeutic effects. THC, the most studied of all the plant's cannabinoids, is psychoactive and is primarily responsible for the plant's influence on mood and behavior. It also possesses various therapeutic effects. Most acknowledged among these are pain relief, appetite stimulation, nausea and vomiting mitigation, anti-spasticity and anti-spasmodic effects, and intraocular pressure reduction in patients with glaucoma. A number of additional, non-psychotropic cannabinoids such as CBD also possess numerous therapeutic properties.

How cannabis interacts with the human body

Scientists are only recently beginning to understand the many complex ways that cannabinoids interact with the human body. Subjects experience psychological and physiological effects after ingesting cannabis because cannabinoids, THC in particular, interact with a complex and dense receptor system within the body.

The CB1 receptors, first identified in the late 1980s, reside predominantly in the nervous system and their stimulation is responsible for the plant's psychoactive and behavioral effects, among other functions. The CB2 receptors, identified in the early 1990s, reside primarily in the immune system and are involved in the moderation of a number of biological functions, including inflammation and pain response. Naturally occurring chemicals in the human body (called endocannabinoids), which possess a similar molecular structure to herbal cannabinoids, act as neuromodulators and cytokine modulators within this receptor system to regulate many of the body's essential physiological functions -- including appetite, blood pressure, reproduction, bone growth, tumor modulation, immunity, inflammation, pain sensation, memory, and muscle tone, among others. It is theorized that a properly functioning endogenous cannabinoid receptor system is necessary for good health and that certain disease types may be the result of deficiencies within this system.

Modulating the activity of the endocannabinoid system ... holds therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.
— National Institutes of Health

What's in the endocannabinoid system?

Remarkable progress has been made in our understanding of the Endocannabinoid System and how it operates in the body through a series of specialized receptors. Since the discovery of this system in the late 1980s, this concept has become the cornerstone of medical cannabis research and how cannabinoids can be used to treat a wide range of ailments.

Homeostasis

The endogenous cannabinoid system or endocannabinoid system, named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, which is a healthy state that is maintained by the constant adjustment of biochemical and physiological pathways.

Cannabinoids promote homeostasis at every level of biological life, from the sub-cellular, to the organism, and beyond. Here's one example: autophagy, a process in which a cell sequesters part of its contents to be self-digested and recycled, is mediated by the cannabinoid system. While this process keeps normal cells alive, allowing them to maintain a balance between the synthesis, degradation, and subsequent recycling of cellular products, it has a deadly effect on malignant tumor cells, causing them to consume themselves in a programmed cellular suicide. The death of cancer cells, of course, promotes homeostasis and survival at the level of the entire organism.

The Bridge

Endocannabinoids and cannabinoids are also found at the intersection of the body's various systems, allowing communication and coordination between different cell types. At the site of an injury, for example, cannabinoids can be found to decrease the release of activators and sensitizers from the injured tissue, stabilizing the nerve cell to prevent excessive firing, and calming nearby immune cells to prevent the release of pro-inflammatory substances. Three different mechanisms of action on three different cell types for a single purpose: minimize the pain and damage caused by the injury.

The endocannabinoid system, with its complex actions in our immune system, nervous system, and all of the body's organs, is literally a bridge between body and mind. By understanding this system we begin to see a mechanism that explains how states of consciousness can promote health or disease.

In addition to regulating our internal and cellular homeostasis, cannabinoids influence a person's relationship with the external environment. Socially, the administration of cannabinoids clearly alters human behavior, often promoting sharing, humor, and creativity. By mediating neurogenesis, neuronal plasticity, and learning, cannabinoids may directly influence a person's open-mindedness and ability to move beyond limiting patterns of thought and behavior from past situations. Reformatting these old patterns is an essential part of health in our quickly changing environment.

What are cannabinoid receptors?

Cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system. When cannabinoid receptors are stimulated, a variety of physiologic processes ensue. Researchers have identified two cannabinoid receptors: CB1, predominantly present in the nervous system, connective tissues, gonads, glands, and organs; and CB2, predominantly found in the immune system and its associated structures. Many tissues contain both CB1 and CB2 receptors, each linked to a different action. Researchers speculate there may be a third cannabinoid receptor waiting to be discovered.

The body and the plant

Endocannabinoids are the substances our bodies naturally make to stimulate these receptors. The two most well understood of these molecules are called anandamide and 2-arachidonoylglycerol (2-AG). They are synthesized on-demand from cell membrane arachidonic acid derivatives, have a local effect and short half-life before being degraded by the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Phytocannabinoids are plant substances that stimulate cannabinoid receptors. Delta-9-tetrahydrocannabinol, or THC, is the most psychoactive and certainly the most famous of these substances, but other cannabinoids such as cannabidiol (CBD) and cannabigerol (CBG) are gaining the interest of researchers due to a variety of healing properties.

Interestingly, the cannabis plant also uses THC and other cannabinoids to promote its own health and prevent disease. Cannabinoids have antioxidant properties that protect the leaves and flowering structures from ultraviolet radiation - cannabinoids neutralize the harmful free radicals generated by UV rays, protecting the cells. In humans, free radicals cause aging, cancer, and impaired healing. Antioxidants found in plants have long been promoted as natural supplements to prevent free radical harm.

Glossary

Below you will find common terms and definitions used in the cannabis industry.